Table 7

DvAL afforded by s.c. dosing as estimated by noncompartmental and compartmental (NONMEM) analysis

DoseDosing RouteNoncompartmentalCompartmental
MIU/kg
IL-2
 0.1s.c./i.v. 15-min infusion168.9
 0.1s.c./i.v. bolus6.66.4
 0.16, 1.0, 1.6, and 3.0s.c./i.v. bolusN.A.7-a 2.5
PEG-IL-2
 0.01, 0.03, and 0.1s.c./15-min i.v. infusion3.82.4
  • 7-a N.A., not available.