Table 6

Summary of results of NONMEM analysis of PEG-IL-2 data after i.v. and s.c. administration to pigs

Parameter6-aUnitEstimateS.E.% RSELCI 95%UCI 95%
CL10ml/h/kg5.870.89715.37.634.11
CL12ml/h/kg1.250.43735.02.110.39
CL216-b ml/h/kg0.33Fixed
CL13ml/h/kg8.400.96811.510.306.50
Vcml/kg12317.214.0156.789.3
Vlyml/kg20.18.1440.536.054.15
V3ml/kg22968.329.8362.995.1
kalymph h−1 3.891.3835.56.591.19
kacentral h−1 9.631.8018.713.166.10
F1.00Fixed
Error0.1550.062740.50.280.03
  • RSE, relative standard error; LCI 95%, lower value of the 95% confidence interval; UCI 95%, upper value of the 95% confidence interval.

  • 6-a See Fig. 1 for definition of parameters and structural model (model B).

  • 6-b CL21 fixed as CL12/0.33 from a noncompartmental analysis of AUCL/AUCP after i.v. dosing (n = 3).