Table 5

Summary of results of NONMEM analysis of IL-2 data after i.v. and s.c. administration to pigs

Parameter5-aUnitEstimateS.E.% RSELCI 95%UCI 95%
CL10ml/h/kg29946.515.6207.9390.1
CL12ml/h/kg61.28.5013.944.577.9
CL215-b ml/h/kg0.67Fixed
CL13ml/h/kg28114250.52.7559.3
CL25ml/h/kg58.519.433.220.596.5
Vcml/kg20167.233.469.3332.7
Vlyml/kg20.65.2025.210.430.8
V3ml/kg24349.820.5145.4340.6
V5ml/kg16226.316.2110.5213.5
kalymph, loh−1 0.3850.094124.40.2010.569
kalymph, med, hih−1 234,000 × ka ly, lo135,000 × ka ly, lo57.7191,961−11,781
kacentral h−1 0.00Fixed
Fs.c.0.4220.03438.10.3550.489
Finf0.2780.068624.70.1440.412
Fbol, lo0.3900.065416.80.2620.518
Fbol, med, hi1.00Fixed
Error plasma2.801.1139.6
Error lymph36.04.3812.2
  • RSE, relative standard error; LCI 95%, lower value of the 95% confidence interval; UCI 95%, upper value of the 95% confidence interval.

  • 5-a See Fig. 1 for definition of parameters and structural model (model A).

  • 5-b CL21 fixed as CL12/0.67 from a noncompartmental analysis of AUCL/AUCP after i.v. dosing (n = 6).