Table 4

Summary of noncompartmental analysis of plasma and lymph data in pigs receiving PEG-IL-2^4-a

Regimen	Dose	Plasma Data		Lymph Data		AUC_L/AUC_P^4-a
Regimen	Dose	AUC_P^4-a		CL/F^4-a ^4-b	V_ss/F^4-a ^4-c	AUC_L/AUC_P^4-a	MRT^4-d	t_1/2^4-d	AUC_L^4-a		t_1/2^4-d
	MIU/kg	ng · h/ml	I.U. · h/ml^4-e	ml/h/kg	ml/kg	h		ng · h/ml	I.U. · h/ml^4-e	h
i.v. 15-min infusion	0.01	249 ± 24 (10)	996	10.1 ± 1.0 (10)	82.4 ± 8.4 (10)	8.25	6.29	82.4 ± 10.7 (13)	330	7.19	0.33 ± 0.07 (22)
s.c. bolus	0.01	403 ± 148 (37)	1612	7.07 ± 3.29 (46)	240 ± 66 (27)	32.4	21.8	467 ± 424 (91)	1868	12.5	1.20 ± 0.99 (83)
s.c. bolus	0.03	932 ± 431 (46)	3728	9.09 ± 3.39 (37)	301 ± 77 (26)	23.7	14.4	962 ± 69 (7)	3848	10.2	1.18 ± 0.49 (41)
s.c. bolus	0.1	1494 ± 671 (45)	5976	19.7 ± 9.1 (46)^4-150	415 ± 212 (51)^4-150	22.8	13.1	1856 ± 504 (27)	7424	10.7	1.36 ± 0.42 (31)

↵4-a Data are mean ± S.D.; numbers in parentheses represent coefficient of variation as a percentage.
↵4-b CL/F significantly different when stratified by route and dose level (P = .04).
↵4-c V_ss/F was significantly different when stratified by route and dose level (P = .04).
↵4-d Harmonic mean is reported for MRT and half-life.
↵4-e A specific activity of 4 MIU/mg was used to convert the PEG-IL-2 data from mass units (mg) to activity units (I.U.).
↵4-150 Comparisons of all pairs using Tukey-Kramer HSD showed that mean values for s.c. bolus, dose level 0.1 MIU/kg, was significantly different from the 0.01 MIU/kg for CL/F. For V_ss/F, the mean for s.c. bolus, dose level 0.1 MIU/kg, was significantly different from the i.v. 15-min infusion dose group.