Table 3

Summary of noncompartmental analysis of plasma and lymph data in pigs receiving IL-2

PartRegimenDosePlasma DataLymph DataAUCL/AUCP3-a
AUCP3-aCL/F3-a3-bVss/F3-a3-cMRT3-dt1/23-dAUCL3-at1/23-d
MIU/kg ng · h/ml I.U. · h/ml3-e ml/h/kg ml/kg h ng · h/ml I.U. · h/ml3-e h
IIi.v. 15-min infusion0.14.02  ± 1.64 (41)641629  ± 633 (39)1467  ± 360 (25)0.910.712.71  ± 1.46 (54)430.800.65  ± 0.16 (25)
IIi.v. bolus0.19.35  ± 1.38 (15)150678  ± 93 (14)640  ± 117 (18)0.941.366.56  ± 1.32 (20)1052.250.70  ± 0.09 (13)
Ii.v. bolus0.1642.4  ± 11.3 (27)678246  ± 58 (24)3-150 340  ± 41 (12)1.371.64 N.A.3-f N.A.N.A.N.A.
Ii.v. bolus1.6363  ± 113 (31)5808299  ± 113 (38)3-150 720  ± 387 (54)2.292.82N.A.N.A.N.A.N.A.
IIs.c. bolus0.113.6  ± 9.0 (66)218553  ± 235 (43)1459  ± 958 (66)4.993.0743.5  ± 3.1 (7)6964.433.50  ± 1.66 (47)
Is.c. bolus0.168.86  ± 2.92 (33)1421238  ± 335 (27)2409  ± 1393 (58)4.442.38N.A.N.A.N.A.N.A.
IIs.c. bolus1.093.9  ± 33.5 (36)1502702  ± 250 (36)1468  ± 533 (36)4.695.65233  ± 73 (31)37283.552.54  ± 0.32 (13)
Is.c. bolus1.6125  ± 55 (44)2000892  ± 314 (35)2673  ± 605 (23)5.693.12N.A.N.A.N.A.N.A.
IIs.c. bolus3.0212  ± 127 (60)33921250  ± 1011 (81)5810  ± 7270 (125)5.864.05873  ± 480 (55)139683.254.10  ± 0.68 (17)
  • 3-a Data are mean ± S.D.; numbers in parentheses represent coefficient of variation as a percentage.

  • 3-b CL/F significantly different when stratified by route and dose level (P = .01).

  • 3-c Vss/F not significantly different when stratified by route and dose level.

  • 3-d Harmonic mean is reported for MRT and half-life.

  • 3-e A specific activity of 16 MIU/mg was used to convert the IL-2 data from mass units (mg) to activity units (I.U.).

  • 3-f N.A., not available.

  • 3-150  Comparisons of all pairs using Tukey-Kramer HSD showed that mean values for i.v. bolus, dose levels 0.16 and 1.6 MIU/kg, were significantly different from all other mean values.