Table 1

Groups, doses, and animal weights

GroupnDoseWeight
MIU/kg kg
IL-2
 Part I: Crossover design1-a 1-b
  i.v. bolus30.1640.5  ± 4.7
  i.v. bolus31.640.5  ± 4.7
  s.c. bolus41-c 0.1638.8  ± 5.1
  s.c. bolus31.640.5  ± 4.7
 Part II: Single-dose design1-d
  i.v. bolus30.124.1  ± 1.3
  15-min i.v. infusion30.122.9  ± 1.9
  s.c. bolus40.123.2  ± 1.3
  s.c. bolus41.021.6  ± 2.9
  s.c. bolus43.023.8  ± 2.9
PEG-IL-2
 15-min i.v. infusion30.0121.6  ± 1.1
 s.c. bolus40.0123.7  ± 1.5
 s.c. bolus40.0322.1  ± 3.7
 s.c. bolus30.1025.6  ± 4.5

Values are mean ± S.D.

  • 1-a Male animals were used in part I.

  • 1-b This study was designed for three animals that received all four treatments sequentially.

  • 1-c A fourth animal was dosed twice with this dose and regimen; therefore, a total of five determinations was made.

  • 1-d Female animals were used in part II.