Combined RI and F2 QTL results for suggestive (LOD > 2.3) and significant (LOD > 3.6) QTLs for both types of cocaine-induced seizures
| Chrom. (RI, F2cM)2-a | RI P Value | F2PValue | Combined P (LOD, sign)2-b | Mode2-c in F2 (h2QTL) |
|---|---|---|---|---|
| Clonic SZ | ||||
| 9:(24, 21) | .40 | 4 × 10−4 | 1.6 × 10−3 (2.2, D2+) | Additive (.06) |
| 9:(61, 55) | .007 | 5 × 10−4 | 5 × 10−5 (3.6, D2+) | B6 dominance (.06) |
| 15:(58, 61) | .15 | 6 × 10−4 | 8 × 10−4 (2.4, B6+) | Additive (.07) |
| Tonic SZ | ||||
| 14:(32, 22) | .0014 | 5 × 10−5 | 1.2 × 10−6 (5.1, D2+) | Additive (.13) |
| 15:(48, 60) | .0025 | 4 × 10−4 | 1.5 × 10−5 (4.1, B6+) | Additive (.05) |
The listed P values are for the location (cM) in both RI and F2 data (given in first column) showing the smallestP value (peak LOD) in a given chromosomal region. Also shown (fourth column) are the combined RI and F2P values using Fisher's method (with corresponding LOD scores) and direction of effect, followed by (last column) mode of F2 inheritance and the heritability of the presumed QTL, orh2QTL in parentheses.
↵2-a Location (cM) of minimum P (peak LOD) for RI and for F2 QTL analyses, respectively.
↵2-b Direction of effect: the allele that is associated with higher threshold values (less sensitivity to seizures).
↵2-c Mode of inheritance (F2 data): if the dominance deviation (d) was less than one fourth of the additive effect (a, also called “weight” in MapMaker QTL), then the QTL was judged to be essentially additive. Dominance here implies complete dominance, or d ≥ a. The heritability of a QTL (h2QTL), or the proportion of the trait variance accounted for by a QTL, was taken from F2 MapMaker QTL output.