Effects of IC injection of vehicle and cumulative doses of the different compounds tested on ICP and BP in anesthetized dogs
| Dose | Prazosin (n = 4) | Phentolamine (n = 3) | Rec 15/2841 (n = 4) | Rec 15/2615 (n = 4) | Rec 15/3039 (n = 4) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| ICP | DBP | ICP | DBP | ICP | DBP | ICP | DBP | ICP | DBP | |
| μg/kg | ||||||||||
| Basal | 16.0 ± 1.6 | 130.5 ± 3.3 | 20.0 ± 2.3 | 128.0 ± 8.0 | 11.5 ± 2.1 | 124.5 ± 3.5 | 14.5 ± 2.2 | 126.5 ± 5.5 | 29.0 ± 6.8 | 120.0 ± 7.4 |
| 3 | n.t. | n.t. | n.t. | n.t. | n.t. | n.t. | 26.7 ± 8.7 | 116.0 ± 2.3 | 30.0 ± 9.5 | 120.7 ± 10.7 |
| 10 | n.t. | n.t. | 24.0 ± 0.0 | 125.3 ± 9.4 | 26.5 ± 8.7 | 116.5 ± 4.8 | 75.0 ± 32.4 | 120.0 ± 5.9 | 47.0 ± 14.1 | 118.0 ± 8.0 |
| 30 | 25.5 ± 6.3 | 116.0 ± 2.9 | 20.0 ± 2.3 | 125.3 ± 7.3 | 28.5 ± 10.0 | 106.5 ± 2.1 | 91.5 ± 26.9a | 117.5 ± 6.5 | 47.0 ± 16.1 | 115.0 ± 7.1 |
| 100 | 27.0 ± 8.7 | 98.5 ± 1.9b | 17.3 ± 1.3 | 118.7 ± 11.2 | 41.0 ± 19.1 | 95.5 ± 6.3b | 95.0 ± 23.3a | 113.0 ± 7.3 | 31.0 ± 12.5 | 109.0 ± 7.8 |
| 300 | 37.5 ± 5.0a | 78.5 ± 3.5b | 16.0 ± 2.3 | 108.7 ± 11.1 | 59.5 ± 19.3b | 81.0 ± 9.0b | 111.0 ± 10.9b | 107.5 ± 7.4 | 52.5 ± 17.7 | 109.0 ± 7.6 |
| 1000 | 52.5 ± 5.0b | 59.0 ± 5.1b | 62.7 ± 24.3a | 91.3 ± 14.7 | 87.0 ± 15.3b | 64.0 ± 9.3b | 116.0 ± 5.2b | 91.0 ± 11.1a | 66.7 ± 15.0 | 105.3 ± 8.5 |
Data represent the mean ± S.E. values of ICP and diastolic BP in mm Hg.
n.t., not tested.
a = P < .05 and b = P < .01 versus basal. n = number of animals tested.