Comparison of −logEC50 for carbamylcholine in stomach fundus, urinary bladder, and trachea from M2 and M4 receptor knockout mice and their wild-type littermates
| Tissue | M4 Mouse Genotype | M2 Mouse Genotype | ||||
|---|---|---|---|---|---|---|
| Wild-type | Knockout | Pvalue | Wild-type | Knockout | P value | |
| −logEC50 ± S.E. (n) | −logEC50 ± S.E. (n) | |||||
| Stomach fundus | 6.76 ± 0.08 (7) | 6.70 ± 0.07 (7) | 0.57 | 6.68 ± 0.07 (7) | 6.39 ± 0.05 (7) | 0.0062 |
| Urinary bladder | 6.30 ± 0.06 (7) | 6.20 ± 0.10 (7) | 0.42 | 6.27 ± 0.07 (7) | 6.07 ± 0.06 (7) | 0.049 |
| Trachea | 6.46 ± 0.10 (3) | 6.62 ± 0.10 (3) | 0.32 | 6.56 ± 0.06 (6) | 6.27 ± 0.11 (6) | 0.029 |
n, number of mice per group.