Recovery of parent compound and 3-OH derivative in urine, bile, and liver
| Urine | Bile | Liver | ||||
|---|---|---|---|---|---|---|
| parent | 3-OH | parent | 3-OH | parent | 3-OH | |
| Bis-quaternary compounds | ||||||
| Pancuronium3-a | 26 | 63-b | 17 | 113-b | 15 | 93-b |
| Dacuronium3-c | 16 | 4 | 18 | 7 | 27 | 9 |
| Org 63683-c | 8 | 3 | 7 | 5 | 26 | 25 |
| Pipecuronium3-d | 533-e | 3-e | 123-e | 3-e | 83-e | 3-e |
| 3-Acetyl, 17-acetyl compound | ||||||
| Vecuronium3-f | 14 | 1 | 39 | 1.5 | 14 | — |
| 3-Acetyl, 17-propionyl compounds | ||||||
| Org 9489 | 5.4 (2.9) | — | 42.8 (3.0) | 8.4 (1.6) | 10.8 (3.9) | 2.0 (0.7) |
| Org 9487 | 8.1 (3.5) | 0.4 (0.0) | 23.5 (7.0) | 5.0 (1.4) | 6.2 (0.3) | — |
| 3-Acetyl, 17-butyryl compounds | ||||||
| Org 9453 | 3.0 (0.7) | 0.4 (0.1) | 61.0 (10.4) | 6.0 (1.3)3-b | 13.2 (6.4) | 9.5 (5.0) |
| Org 7617 | 2.0 (1.3) | 0.4 (0.3) | 23.3 (3.0) | 3.0 (0.8) | 3.9 (0.5) | 16.6 (3.9) |
| Org 9616 | 1.9 (0.6) | 2.1 (0.4) | 38.7 (20.7) | 11.9 (0.8) | —3-g | —3-g |
| Org 9991 | 4.4 (2.2) | 0.1 (0.1) | 15.5 (2.9) | 4.5 (0.8) | 14.4 (5.7) | 2.9 (1.0) |
| 3-OH compounds | ||||||
| Org 7268 | 3.6 (2.0) | x | 44.5 (7.6) | x | 25.5 (9.0) | x |
| Org 20297 | 7.7 (1.6) | x | 59.9 (13.9) | x | 12.2 (2.7) | x |
| 3-Carbamate compound | ||||||
| Org 9955 | 5.7 (1.3) | — | 67.0 (7.6) | — | 11.5 (2.9) | — |
| 3-OH, 2-morpholino compounds | ||||||
| Org 9273 | —3-g | x | —3-g | x | —3-g | x |
| Rocuronium | 1.8 (0.1) | x | 36.9 (8.8) | x | —3-g | x |
| 3-Desoxy compound | ||||||
| Org 20059 | 1.5 (1.1) | x | 31.5 (2.7) | x | 22.1 (13.2) | x |
Recovered amount expressed as percentage of dose (mean values of three experiments with S.D. in parentheses).
—, not found in measurable amounts; x, formation of 3-OH derivative not possible.
↵3-a Data from Agoston et al. (1973) (mean values, n = 7).
↵3-b Amount refers to total of 3-OH, 17-OH, and 3,17-di-OH derivative.
↵3-c Data from Agoston et al. (1977) (mean values, n = 5).
↵3-d Data from Agoston et al. (1988) (mean values, n = 6).
↵3-e Amount refers to total of parent and 3-OH metabolite.
↵3-f Data from Bencini et al. (1985) (mean values, n = 6).
↵3-g Amount not quantified.