Table 1

Pharmacokinetic parameters for benazepril and enalapril after a single oral administration of enalapril or benazepril at a nominal dose of 0.5 mg/kg before and after an experimental renal injury in 10 dogs (noncompartmental analysis) (mean ± S.D.)

Parameters (Units)ControlRenal FailureP Value
AUC(0–tlast) (ng · min/ml)1-a Enalapril Benazepril 2246 ± 1103  995 ± 9122965 ± 1257 1217 ± 8570.067 0.49
Cmax(ng/ml)1-b Enalapril 31.7 ± 16.734.3 ± 14.9NC
Benazepril25.4 ± 16.632.4 ± 22.1NC
Tmax(min)1-c Enalapril43.3 ± 2440.5 ± 18.8NC
Benazepril33.3 ± 12.233.0 ± 17.0NC

  • NC, not calculated.

  • ↵1-a AUC, area under the plasma concentration time curve from time 0 to the last observed concentration.

  • ↵1-b Cmax, the observed maximal plasma concentration.

  • ↵1-c Tmax, time observed for Cmax.