Table 1

Experimental design for nicotine or saline pump implantation and subsequent administration of mecamylamine or naloxone (total of eight injections each, including two of saline), or chlorisondamine (s.c., total of six injections, including one of saline; i.c.v., total of five injections, including one of saline)

Mecamylamine/Naloxone		Chlorisondamine (s.c. or i.c.v.)
Pump Day	Testing	Pump Day	Testing
6	Injection I	6	Injection I
7	baseline session	7	baseline session
8	Injection II	8	baseline session
9	baseline session	9	Injection II
10	Injection III	10	baseline session
11	baseline session	11	baseline session
12	Injection IV	12	Injection III
13	baseline session, new pump in	13	baseline session
14	baseline session	14	baseline session, new pump in
15	Injection V	15	baseline session
16	baseline session	16	Injection IV
17	Injection VI	17	baseline session
18	baseline session	18	baseline session
19	Injection VII	19	Injection V
20	baseline session	20	baseline session
21	Injection VIII	21	baseline session
22	baseline session	22	Injection VI (s.c. chlorisondamine)
		23	baseline session
		24	baseline session