Organ uptake of 125I-8D3 mAb, 125I-RI7 mAb, and125I-OX 26 mAb by BALB/c mice at 60 min after i.v. injection
| Organ | mAb | |||
|---|---|---|---|---|
| 125I-8D3 | 125I-RI7 | 125I-OX 26 | ||
| Vd (μl/g) | V0 (μl/g) | |||
| brain | 7 | 102 ± 8 | 107 ± 17 | 10.7 ± 0.6 |
| liver | 58 | 576 ± 110 | 62 ± 9 | 162 ± 19 |
| kidney | 62 | 213 ± 7 | 110 ± 65 | 136 ± 8 |
| heart | 94 | 131 ± 5 | 159 ± 12 | 87 ± 8 |
| PS (μl/min/g) | ||||
| brain | 1.5 ± 0.1 | 1.2 ± 0.2 | 0.046 ± 0.006 | |
| liver | 8.3 ± 1.8 | 0 | 1.3 ± 0.2 | |
| kidney | 2.4 ± 0.1 | 0 | 0.92 ± 0.09 | |
| heart | 0.59 ± 0.08 | 0.80 ± 0.10 | 0 | |
| %ID/g | ||||
| brain | 3.1 ± 0.4 | 1.6 ± 0.2 | 0.06 ± 0.01 | |
| liver | 16.9 ± 6.1 | 0 | 1.7 ± 0.3 | |
| kidney | 4.9 ± 0.1 | 0 | 1.2 ± 0.1 | |
| heart | 1.2 ± 0.1 | 1.0 ± 0.2 | 0 | |
V0 is organ volume of distribution of 125I-rat IgG2B. Data for all organs were obtained at 60 min after i.v. injection of the isotope solution. Vd of each mAb was determined from the ratio of total organ radioactivity (counts per minute per gram) divided by TCA-precipitable plasma radioactivity (counts per minute per microliter). Data are mean ± S.E. (n = 3).