Response to DPCPX and furosemide in control and PT-treated SD rats
| Treatment | Basal | DPCPX | Furosemide + DPCPX | Repeated-Measures, 2F-ANOVA Statistics | ||
|---|---|---|---|---|---|---|
| PT | Diuretic | Interaction | ||||
| MABP (mmHg) | ||||||
| Control | 137 ± 4 | 140 ± 4 | 137 ± 3 | P < .05 | P < .05 | P < .05 |
| PT-treated | 105 ± 33-a | 110 ± 43-a | 118 ± 43-a 3-b 3-c | |||
| HR (bpm) | ||||||
| Control | 366 ± 9 | 385 ± 103-b | 393 ± 143-b | P < .05 | P < .05 | P = .55 |
| PT-treated | 427 ± 93-a | 445 ± 83-a 3-b | 463 ± 93-a 3-b 3-c | |||
| RBF (ml/min/g kid) | ||||||
| Control | 6.9 ± 0.5 | 6.6 ± 0.4 | 4.8 ± 0.43-b 3-c | P = .13 | P < .05 | P = .55 |
| PT-treated | 6.2 ± 0.5 | 5.5 ± 0.53-a 3-b | 4.0 ± 0.33-a 3-b 3-c | |||
| RVR [mmHg/(ml/min/g kid)] | ||||||
| Control | 20.8 ± 1.3 | 22.0 ± 1.8 | 31.5 ± 3.13-b 3-c | P = .78 | P < .05 | P = .44 |
| PT-treated | 18.1 ± 1.4 | 21.6 ± 1.9 | 32.3 ± 3.23-b 3-c | |||
| GFR (ml/min/g kid) | ||||||
| Control | 1.75 ± 0.14 | 1.79 ± 0.08 | 1.42 ± 0.073-b 3-c | P < .05 | P < .05 | P = .29 |
| PT-treated | 1.15 ± 0.243-a | 0.91 ± 0.183-a | 0.73 ± 0.133-a 3-b | |||
| UV (μl/30 min/g kid) | ||||||
| Control | 272 ± 60 | 1087 ± 1333-b | 1921 ± 1283-b 3-c | P < .05 | P < .05 | P < .05 |
| PT-treated | 156 ± 19 | 192 ± 513-a | 1020 ± 1493-a 3-b 3-c | |||
| UNaV (μmol/30 min/g kid) | ||||||
| Control | 37 ± 11 | 229 ± 313-b | 287 ± 273-b 3-c | P < .05 | P < .05 | P < .05 |
| PT-treated | 11 ± 3 | 18 ± 73-a | 122 ± 213-a 3-b 3-c | |||
| UKV (μmol/30 min/g kid) | ||||||
| Control | 40.9 ± 3.4 | 56.4 ± 3.93-b | 59.7 ± 4.53-b | P < .05 | P < .05 | P < .05 |
| PT-treated | 11.5 ± 1.23-a | 8.9 ± 1.33-a | 24.4 ± 3.03-a 3-b 3-c | |||
Means ± S.E. in 12 control and 12 PT-treated SD rats. Data were analyzed by repeated-measures, 2F-ANOVA, and Fisher's LSD test.