SCH-23,390 | Time (min) | ||
---|---|---|---|
0 | 60 | 240 | |
μmol/kg | °C | ||
0 | 38.7 ± 0.1 | 38.5 ± 0.1 | 38.2 ± 0.3 |
0.04 | 39.2 ± 0.2 | 38.4 ± 0.3 | 38.0 ± 0.1 |
0.30 | 38.6 ± 0.2 | 38.6 ± 0.1 | 38.0 ± 0.3 |
0.60 | 39.0 ± 0.1 | 38.5 ± 0.1 | 38.0 ± 0.1 |
Mean ± S.D. core temperature is given at the various doses and time intervals used. Control values were pooled from four separate experiments, 0.3 μmol/kg values from three experiments (cf. Fig. 2), and 0.04 and 0.60 μmol/kg values from one experiment based on repeated observations of six animals in each experiment. One-way ANOVAs, using the appropriate controls, did not disclose any statistically significant effects of SCH-23,390 in any dose or at any time interval (P > .05).