Effects of antiemetics on copper sulfate-induced delayed emesis in the dog
| Treatment | Dose3-a | Animals | Latencyb | Emetic Episodes | Inhibition |
|---|---|---|---|---|---|
| mg/kg i.v. | vomits/ total | min | n | % | |
| Control | 3 /3 | 7.7 ± 1.8 | 10.7 ± 4.4 | ||
| FK1052 | 1 | 3 /3 | 7.4 ± 1.6 | 5.3 ± 2.8 | 50.5 |
| 3.2 | 3 /3 | 10.4 ± 3.7 | 2.3 ± 0.3 | 78.5 | |
| Ondansetron | 1 | 3 /3 | 8.6 ± 3.2 | 8.0 ± 2.0 | 25.2 |
| Tropisetron | 1 | 3 /3 | 6.8 ± 1.5 | 6.3 ± 1.5 | 40.2 |
| CP-122,721 | 0.1 | 3 /3 | 16.1 ± 1.9 | 3.3 ± 1.2 | 69.2 |
↵3-a Antiemetics were administered i.v. 10 min before the administration of copper sulfate.