Effect of chronic i.p. treatment with FA70 and clorgyline on MAO-A and MAO-B activity in mouse cortex
| MAO Activity | ||
|---|---|---|
| MAO-A | MAO-B | |
| pmol/min · mg protein | ||
| FA70 | ||
| Control | 670 ± 14 | 410 ± 16 |
| Acute | 68 ± 5** | 422 ± 22 |
| Chronic | 54 ± 6** | 451 ± 16 |
| Clorgyline | ||
| Control | 670 ± 14 | 410 ± 16 |
| Acute | 107 ± 7** | 336 ± 203-150 |
| Chronic | 84 ± 6** | 320 ± 243-150 |
Mice received 5 mg/kg of FA70 and clorgyline i.p. once (acute) or once daily for 21 days (chronic). Animals were sacrificed 24 h after treatment. Means ± S.E. for 6 to 10 animals per group are shown.
↵3-150 P < .01, ** P < .001 compared with control.