Ex vivo effects of FA70 and clorgyline on MAO-A activity in mouse
| ED50 | ||
|---|---|---|
| Cortex | Liver | |
| mg/kg | ||
| FA70 | 0.75 ± 0.42 | >10 (30%)2-a |
| Clorgyline | 1.75 ± 0.12 | 1.40 ± 0.15 |
Mice were treated i.p. with FA70 and clorgyline 2 h before sacrifice. Control MAO-A activity (picomoles per minute · milligram protein): cortex, 794 ± 10; liver, 205 ± 5. Means ± S.E. for 6 to 10 animals per group are shown.
↵2-a Percentage of inhibition at this dose.