Relative activity (RA) and EC50 of α2-adrenergic agonists in stimulating [35S]GTPγS binding to PC12/α2A/D-membranes
| Agonist | RA in [35S]GTPγS Binding | EC50 |
|---|---|---|
| μM | ||
| Epinephrine | 1.00 ± 0 | 0.14 ± .01 |
| Norepinephrine | 0.85 ± .04 | 0.50 ± .07 |
| Deoxyepinephrine | 0.78 ± .07 | 1.9 ± 1.1 |
| UK14304 | 0.78 ± .05 | 0.02 ± .008 |
| Synephrine | 0.47 ± .01 | 6.4 ± .15 |
| BHT-933 | 0.46 ± .03 | 0.37 ± .06 |
| Clonidine | 0.38 ± .01 | 0.014 ± .007 |
| Oxymetazoline | 0.32 ± .05 | 0.003 ± .001 |
| Phenylephrine | 0.29 ± .01 | 1.6 ± .45 |
| Norphenylephrine | 0.28 ± .01 | 6.3 ± 1.8 |
| R-(−)-OH-3,4-OH-Tolazoline | 0.72 ± .06 | 0.14 ± 1.0 |
| S-(+)-OH-3,4-OH-Tolazoline | 0.31 ± 0.23 | 2.5 ± 1.6 |
Values of RA and EC50 are means ± S.E. for at least two separate experiments.