Characteristics of NaF concentration-response curves in the absence and presence of 1 μM nifedipine in control and diabetic vessels
| Aorta | Mesenteric Artery | |||
|---|---|---|---|---|
| EC501-a | Maximum response | EC501-a | Maximum response | |
| mM | mg/mg wet weight | mM | mg/mg wet weight | |
| Control | ||||
| Untreated | 4.1 ± 0.1 | 97.5 ± 7.0 | 5.7 ± 0.5 | 814 ± 62 |
| Nifedipine | 7.7 ± 0.21-159 1-159 1-159 | 107.2 ± 7.2 | 8.6 ± 0.31-159 1-159 1-159 | 558 ± 941-159 |
| Diabetic | ||||
| Untreated | 5.3 ± 0.31-150 | 144.1 ± 8.1*** | 4.7 ± 0.5 | 1329 ± 132** |
| Nifedipine | 8.8 ± 0.41-159 1-159 1-159 | 106.8 ± 8.31-159 1-159 | 10.1 ± 0.41-159 1-159 1-159 | 574 ± 821-159 1-159 |
The values are expressed as means ± S.E. of 6 to 12 experiments.
↵1-a The EC50 values were obtained from the lines that are computer generated curves fitting the observed data points.
↵1-150 P < .05, ** P < .01, *** P < .001 versus the respective control data.
↵1-159 P < .05,## P < .01,### P < .001 versus the respective data from untreated preparations.