Oligonucleotide sequence and modifications
| Compound | Molecular Target | Sequence (5′ → 3′) |
|---|---|---|
| ISIS 1082 | Herpes virus | GsCsCsGsAsGsGsTsCsCsAsTsGsTsCsGsTsAsCsGsC |
| ISIS 13108 | Herpes virus | GsC*sC*sGsAsGsGsTsC*sC*sAsTsGsTsC*sGsTsAsC*sGsC* |
| ISIS 12449 | None | AsCsCsGsAsTsAsAsCsGsTsTsGsCsCsGsGsTsGsAsCsG |
| ISIS 5132 | Human C-raf kinase | TsCsCsCsGsCsCsTsGsTsGsAsCsAsTsGsCsAsTsT |
| ISIS 12959 | Baboon C-raf kinase | TsCsTsCsAsCsCsTsGsTsGsAsCsAsTsGsCsAsTsT |
| ISIS 12854 | Human C-raf kinase | ToC*oC*oC*oGoCsCsTsGsTsGsAsCsAsToGoC*oAoToT |
| ISIS 13650 | Human C-raf kinase | TsC*sC*sC*sG7sCsCsTsGsTsGsAsCsAsTsGsC*sAsTsT |
C, deoxynucleotide; C*, 5-methyl C; T, 2′-MDE; s, phosphorothioate linkage; and o, phosphodiester linkage.