Effect of BBT and hyperoxia on liver CYP enzymes
| Treatment | Total CYP Content | PROD | EROD | MROD |
|---|---|---|---|---|
| nmol/min/mg | ||||
| Vehicle | 0.52 ± 0.037 | 0.25 ± 0.064 | 0.72 ± 0.011 | 1.11 ± 0.08 |
| BBT | 0.44 ± 0.019 | 0.29 ± 0.044 | 0.64 ± 0.05 | 1.13 ± 0.17 |
| Vehicle + hyperoxia | 0.49 ± 0.052 | 0.22 ± 0.057 | 0.77 ± 0.015 | 1.01 ± 0.07 |
| BBT + hyperoxia | 0.38 ± 0.070 | 0.20 ± 0.024 | 0.60 ± 0.07 | 0.83 ± 0.11 |
Total liver microsomal CYP contents and activities of PROD, EROD, and MROD were determined in vehicle- and BBT-treated animals exposed to room air or hyperoxia. All values represent means ± S.E. of samples from four individual animals. Statistical analyses were performed by two-way ANOVA, followed by modified t tests. Total CYP contents and activities of PROD, EROD, and MROD did not differ significantly among any of the groups.