Generalization of S18327 to a clozapine discriminative stimulus and actions of S18327 in models of potential anxiolytic activity
| Clozapine generalization | Vogel Test ↑ Punished responses | ↓ Ultrasonic vocalizations | Aggressive Behavior | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ↓ Number fights | ↓ Duration fights | |||||||||
| ED50 (95% CL) | %MOG (dose) | MED | %MOE (dose) | ID50 (95% CL) | %MOE (dose) | ID50 (95% CL) | %MOE (dose) | ID50 (95% CL) | %MOE (dose) | |
| S18327 | 0.6 (0.3–1.6) | 80 (2.5) | 2.5 | 38 (2.5) | 0.07 (0.02–0.2) | 96 (0.63) | 0.2 (0.09–0.4) | 100 (2.5) | 0.2 (0.08–0.4) | 100 (2.5) |
ED50 (95% CL), effective dose50 (95% confidence limits); ID50, inhibitory dose50; %MOG, %maximal observed generalization (dose at which obtained); %MOE, %maximal observed effect (dose at which obtained); MED, minimal effective dose. Doses are in mg/kg, s.c.