Actions of S18327 in diverse models of potential antipsychotic activity
| S18327 | ||
|---|---|---|
| ID50 (95% CL) | % MOE (dose) | |
| Apomorphine climbing | 0.2 (0.1–0.5) | 100 (2.5) |
| Conditioned avoidance responses | 0.8 (0.2–1.7) | 98 (5.0) |
| Amphetamine locomotion | 1.3 (0.14–12.1) | 98 (10.0) |
| Cocaine locomotion | 0.7 (0.3–1.5) | 80 (2.5) |
| DOI head twitches | 0.1 (0.07–0.14) | 91 (0.16) |
| PCP locomotion | 0.1 (0.02–0.4) | 100 (0.31) |
| Dizocilpine locomotion | 0.9 (0.4–2.2) | 95 (10.0) |
| Dizocilpine STF | 1.7 (0.8–3.8) | 97 (10.0) |
PCP, phencyclidine; DOI, (1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane); STF, spontaneous tail-flicks; ID50 (95% CL), inhibitory dose50 (95% confidence limits); %MOE, % maximal observed effect (dose at which obtained). Doses are in mg/kg, s.c.