Potency (pEC503-a) and maximal effect (Emax) values for ET receptor agonists in human right atrium
| Drug | n | Basal force | pEC50 | Emax | Emax |
|---|---|---|---|---|---|
| mN | mN | % Ca2+b | |||
| ET-1 | 53 | 5.3 ± 0.7 | 8.0 ± 0.1 | 12.5 ± 1.1 | 48.9 ± 2.6 |
| ET-2 | 7 | 5.6 ± 1.2 | 8.1 ± 0.1 | 13.3 ± 1.6 | 51.5 ± 4.8 |
| ET-3 | 6 | 9.3 ± 2.3 | 7.7 ± 0.1 | 17.8 ± 2.3 | 61.0 ± 6.1 |
| Sarafotoxin S6c | 17 | 5.3 ± 1.3 | 8.6 ± 0.1 | 7.9 ± 1.2 | 23.7 ± 3.3 |
Values are means ± S.E. from n patients. There were no differences in basal values between groups (P = .3).
↵3-a −Log EC50.
3-b Maximal response expressed as a percentage of the response to 9.25 mM Ca2+.