Table 2

Body weight gains and organ weights of hypophysectomized male rats receiving renaturalized masculine profiles of circulating GH

Treatment	% Control Pulse	Body Weight Gain	Liver	Kidneys	Testes	Seminal Vesicles	Adrenals
μg rGH/kg/pulse		g/week	mg/100 g b.wt.
0	0	−1.8 ± 0.8^2-150	2962 ± 145^2-150	543 ± 35^2-150	184 ± 14^2-150	30 ± 3^2-150	7.2 ± 1.1^2-150
0.02	0.05	−2.0 ± 2.5^2-150	3064 ± 81^2-150	512 ± 59^2-150	188 ± 14^2-150	29 ± 6^2-150	7.1 ± 1.6^2-150
0.04	0.1	−2.3 ± 2.1^2-150	2891 ± 296^2-150	511 ± 40^2-150	183 ± 32^2-150	33 ± 7^2-150	7.2 ± 1.7^2-150
0.1	0.25	−1.3 ± 2.3^2-150	3059 ± 234^2-150	536 ± 37^2-150	187 ± 20^2-150	28 ± 6^2-150	7.3 ± 0.9^2-150
0.2	0.5	−1.7 ± 1.4^2-150	3037 ± 242^2-150	536 ± 38^2-150	186 ± 14^2-150	30 ± 4^2-150	7.5 ± 1.2^2-150
0.4	1	−3.7 ± 2.3^2-150	3051 ± 113^2-150	544 ± 43^2-150	198 ± 17^2-150	29 ± 5^2-150	9.4 ± 0.8^2-150
1	2.5	−1.3 ± 2.6^2-150	3058 ± 338^2-150	533 ± 40^2-150	192 ± 33^2-150	29 ± 5^2-150	9.3 ± 0.9^2-150
2	5	5.8 ± 2.3^2-150 ^, ^†	3186 ± 226^2-150	548 ± 55^2-150	230 ± 29^2-150	33 ± 6^2-150	9.3 ± 0.8^2-150
4	10	7.3 ± 3.3^2-150 ^, ^†	3245 ± 200^2-150	552 ± 40^2-150	242 ± 30^2-150 ^, ^†	34 ± 5^2-150	9.4 ± 0.9^2-150
10	25	16.0 ± 3.1^†	3348 ± 162^†	553 ± 29^2-150	254 ± 33^2-150 ^, ^†	40 ± 4^2-150 ^, ^†	9.1 ± 1.1^2-150
20	50	18.2 ± 3.7^†	3460 ± 209^†	640 ± 23^†	263 ± 38^2-150 ^, ^†	44 ± 6^2-150 ^, ^†	12.8 ± 1.8^†
40	100	21.6 ± 5.1^†	3609 ± 225^†	629 ± 19^†	391 ± 46^2-150 ^, ^†	55 ± 3^2-150 ^, ^†	12.3 ± 1.5^†
Intact		19.0 ± 3.2	3689 ± 146	671 ± 25	657 ± 38	78 ± 5	12.7 ± 0.8

Masculine-like plasma growth hormone profiles were restored to hypophysectomized male rats by administering rGH in six daily pulses, once every 4 h, through an external pump attached to an indwelling atrial catheter (Pampori et al., 1991a). Various concentrations of rGH (μg/kg b.wt.) were infused per pulse (column 1) to replicate 0 to 100% (column 2) normal pulse parameters. After 7 d of GH replacement, the rats were euthanized and necropsied. Values are means ± S.D. for at least six rats.

↵2-150 P < .01 compared with the intact male rats.
^† P < .01 compared with the vehicle-treated (0%) hypophysectomized male rats.