Table 1

Effect of Macrolide Antibiotics and Indomethacin on Rat Carrageenin-Induced Pleurisy

TreatmentExudate VolumeCellsNOxPGE2LTB4TNF-αn
mg/kg/p.o. ml ×106 μg ng ng ng
Control0.70  ± 0.03126.6  ± 5.61.51  ± 0.060.428  ± 0.012.50  ± 0.152.14  ± 0.1735
Roxithromycin
 100.65  ± 0.05119.8  ± 5.61.58  ± 0.040.410  ± 0.062.54  ± 0.151.81  ± 0.119
 200.45  ± 0.09** 101.3  ± 6.11-150 0.99  ± 0.07*** 0.338  ± 0.031-150 2.30  ± 0.141.32  ± 0.111-150 8
 400.35  ± 0.1*** 88.5  ± 7.5** 0.75  ± 0.03*** 0.253  ± 0.03*** 2.15  ± 0.251.13  ± 0.08** 7
Clarithromycin
 100.75  ± 0.09123.0  ± 7.91.44  ± 0.100.399  ± 0.062.60  ± 0.121.99  ± 0.137
 200.55  ± 0.12107.6  ± 8.91.18  ± 0.071-150 0.329  ± 0.041-150 2.40  ± 0.111.54  ± 0.201-150 9
 400.4  ± 0.08** 88.2  ± 11** 0.88  ± 0.05*** 0.244  ± 0.03*** 2.03  ± 0.211.13  ± 0.12** 9
Erythromycin
 100.65  ± 0.08123.9  ± 2.91.39  ± 0.050.401  ± 0.042.37  ± 0.121.92  ± 0.079
 200.60  ± 0.1093.6  ± 8.31-150 1.07  ± 0.11** 0.261  ± 0.06*** 2.12  ± 0.281.52  ± 0.081-150 8
 400.35  ± 0.05*** 86.6  ± 6.3** 0.85  ± 0.04*** 0.201  ± 0.02*** 1.87  ± 0.271.03  ± 0.10** 8
Azithromycin
 100.65  ± 0.04122.8  ± 4.81.34  ± 0.140.412  ± 0.062.47  ± 0.222.17  ± 0.087
 200.65  ± 0.03105.0  ± 8.11.14  ± 0.220.347  ± 0.052.25  ± 0.301.91  ± 0.089
 400.65  ± 0.06102.5  ± 6.21-150 1.05  ± 0.091-150 0.325  ± 0.051-150 2.07  ± 0.351.38  ± 0.17** 8
Indomethacin
  50.19  ± 0.01*** 87.3  ± 7.51-150 0.98  ± 0.091-150 0.05  ± 0.01*** 2.35  ± 0.14.1  ± 0.18*** 8

Results are given per rat (mean ± S.E.).

  • ↵1-150  P < .05, ** P < .01, *** P < .001 versus control.