Table 3

IC50s of inhibition of KATP in aorta cells versus β-cells

Compoundβ-CellRat Aorta CellRatio (R/β)
μM mM
NAT7.4  ± 0.20.33  ± 0.043-a 45
nM
GLY16.6  ± 0.338.8  ± 9.5 2 (N.S.)
REP5.0  ± 1.478.7  ± 15.43-a 16

  • N.S., not significant.

  • ↵3-a Significantly different from the corresponding values in β-cell.