l-Glu | GABA | |
---|---|---|
pmol · mg−1 protein · min−1 | ||
Control | 40.8 ± 1.0 | 8.4 ± 0.2 |
DT1 (0.3 μM) | 40.0 ± 1.9 | 8.5 ± 0.5 |
(−)-U50,488 (3 μM) | 38.7 ± 1.3 | 8.0 ± 0.4 |
EM1 (1 μM) | 36.8 ± 0.61-a | 8.0 ± 0.2 |
EM1 (1 μM) + Nal (1 μM) | 40.1 ± 1.1 | 8.3 ± 0.3 |
NC (1 μM) | 41.2 ± 1.1 | 8.5 ± 0.3 |
Effects of opioids and nociceptin on spontaneous l-Glu and GABA efflux from rat cerebrocortical synaptosomes. Neurotransmitter efflux is expressed in absolute values. Data are means ± S.E. of at least 6 to 10 experiments. For details, see Materials and Methods.
↵1-a p < .05, statistically different from control.