Pharmacokinetic variables for recirculatory inulin pharmacokinetics
| Experimental Condition | Volume3-a | Clearance3-b | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| VC3-c | VND-F3-c | VND-S | VT-F | VT-S | VSS | ClND-F3-c | ClND-S | ClT-F | ClT-S | ClE | ΣCl | |
| liters | liters/min | |||||||||||
| Volume loaded | 1.10 | 0.593-d | 1.50 | 3.27 | 3.45 | 9.92 | 4.973-d | 2.40 | 0.57 | 0.09 | 0.19 | 8.22 |
| (0.08) | (0.15) | (0.52) | (0.41) | (0.90) | (1.32) | (2.18) | (0.61) | (0.10) | (0.04) | (0.03) | (1.74) | |
| Normovolemic | 1.03 | 0.32 | 1.45 | 3.39 | 4.57 | 10.77 | 3.23 | 2.40 | 0.61 | 0.11 | 0.20 | 6.53 |
| (0.08) | (0.23) | (0.27) | (0.96) | (0.82) | (1.43) | (1.71) | (0.49) | (0.16) | (0.02) | (0.02) | (2.05) | |
| Mildly | 0.863-d 3-e | 0.123-d 3-e | 1.33 | 2.95 | 4.07 | 9.33 | 1.433-d 3-e | 2.33 | 0.49 | 0.09 | 0.18 | 4.523-d 3-e |
| hypovolemic | (0.03) | (0.08) | (0.20) | (0.79) | (1.05) | (1.14) | (1.10) | (0.40) | (0.05) | (0.02) | (0.04) | (1.29) |
| Moderately | 0.713-d 3-e 3-f | 0.133-d 3-e | 1.11 | 2.43 | 4.14 | 8.53 | 1.153-d 3-e | 2.01 | 0.42 | 0.09 | 0.17 | 3.853-d 3-e |
| hypovolemic | (0.18) | (0.05) | (0.22) | (0.22) | (0.69) | (1.13) | (0.75) | (0.87) | (0.17) | (0.04) | (0.02) | (1.70) |
Values are mean (S.D.).
↵3-a The volumes (V) of the central (C), rapidly equilibrating (fast) nondistributive (ND-F), and slowly equilibrating nondistributive (ND-S) circuits and the rapidly equilibrating (fast) (T-F) and slowly equilibrating (T-S) tissues, and VSS, which equals the sum of all volumes.
↵3-b The clearances (Cl) of the rapidly equilibrating (fast) nondistributive (ND-F) and slowly equilibrating nondistributive (ND-S) circuits and the rapidly equilibrating (fast) (T-F) and slowly equilibrating (T-S) tissues, ClE, and ΣCl, which equals the ICG (dye dilution) CO determined at the moment of marker injection.
↵3-c Correlated with CO (p < .05).
↵3-d Significantly different from normovolemic control (p < .05), as determined by Fisher's LSD test.
↵3-e Significantly different from volume loaded (p < .05), as determined by Fisher's LSD test.
↵3-f Significantly different from mildly hypovolemic (p < .05), as determined by Fisher's LSD test.