Disposition kinetics of deuterium-labeled nicotine and cotinine
| Nicotine | Cotinine | |||
|---|---|---|---|---|
| Blacks (n = 51) | Whites (n = 57) | Blacks (n = 51) | Whites (n = 57) | |
| CLT(ml/min/kg) | 18.1 (16.7–19.5) | 20.5 (18.0–22.9) | 0.57** (0.53–0.62) | 0.76 (0.67–0.85) |
| CLNR(ml/min/kg) | 17.5 (16.1–18.8) | 20.0 (17.5–22.4) | 0.49*** (0.44–0.53) | 0.72 (0.63–0.80) |
| CLR(ml/min/kg) | 0.64 (0.46–0.83) | 0.49 (0.35–0.63) | 0.08*** (0.07–1.00) | 0.05 (0.04–0.06) |
| Vss(liters/kg) | 2.9 (2.7–3.2) | 3.3 (3.0–3.6) | 0.81** (0.78–0.85) | 0.93 (0.87–1.00) |
| T 1/2(min) | 131 (123–139) | 136 (124–147) | 10852-150 (1013–1156) | 961 (881–1042) |
| fNIC→COT | 0.812-150 (0.79–0.83) | 0.86 (0.83–0.88) | ||
| CLNIC→COT (ml/min/kg) | 14.82-150 (13.5–16.0) | 17.7 (15.5–20.0) | ||
CLT, total plasma clearance; CLNR, nonrenal clearance; CLR, renal clearance; Vss, steady-state volume of distribution; T1/2, half-life; fNIC→COT, fractional conversion of nicotine to cotinine; CLNIC→COT, metabolic clearance of nicotine to cotinine.
↵2-150 P < .05, ** P < .01 for blacks versus whites, *** P < .001; mean (95% CI).