Pharmacological potencies of nicotinic ligands in inducing seizures after s.c. administration in mice
| Drug | ED50 |
|---|---|
| mg/kg | |
| (−)-Epibatidine | 0.029 (0.01–0.04) |
| (+)-Epibatidine | 0.021 (0.005–0.04) |
| 6-Chloronicotine | 0.74 (0.42–0.87) |
| (−)-Nicotine | 4.8 (4.1–5.3) |
| (+)-Nicotine | 103 (81–130) |
| AMP-MP | 300 (180–358) |
| Anabasine | 0% at 100 |
| N-MNP | 0% at 200 |
| AMP-ME | 300 (287–304) |
| Cytisine | 33% at 15 |
| Lobeline | 50% at 50 |
| (±)-Isonicotine | 0% at 200 |
| Metanicotine | 0% at 100 |
| Cotinine | 0% at 100 |
Values are expressed as ED50 ± 95% CL or as the percentage of animals producing seizures at the highest dose tested. At least six to eight mice were tested at each dose.