Table 1

In vivo apparent pK_B analysis of antagonism of the discriminative stimulus and rate-altering effects of zolpidem and midazolam in squirrel monkeys

Drug	Flumazenil Dose
	% Drug-Lever Responding		Response Rate
	0.1	1.0	0.1	1.0
	mg/kg
Zolpidem^1-a	7.3	7.2	6.9	6.7
Zolpidem, 95% CI^1-a	6.9–7.7	6.9–7.5	5.9–7.9	5.8–7.6
Midazolam^1-b	7.5	7.1	—^1-c	6.1

Apparent pK_B values for midazolam are from midazolam-trained monkeys (Spealman, 1985), as calculated by Rowlett and Woolverton (1996).

↵1-a Data from present study.
↵1-b Data from midazolam-trained monkeys.
↵1-c —, no effect of flumazenil at the indicated dose.