Agonist | IC50 | EC50 | Emax(U) |
---|---|---|---|
l-Nicotine | 26 ± 11 | 1630 ± 500 | 0.83 ± 0.05 |
d-Nicotine | 1050 ± 400 | 12,800 ± 2920 | 0.50 ± 0.05 |
Cytisine | 15 ± 6 | 5 ± 7 | 0.29 ± 0.04 |
Ach | 76 ± 29 | 1610 ± 170 | 1.16 ± 0.03 |
Methylcarbachol | 56 ± 14 | 6890 ± 2380 | 1.37 ± 0.14 |
Dimethylphenylpiperazimuam | 400 ± 60 | 6750 ± 1790 | 1.16 ± 0.05 |
Carbachol | 1600 ± 800 | 32,400 ± 12,100 | 1.27 ± 0.05 |
Tetremethylammonium | 1400 ± 300 | 42,260 ± 15,310 | 1.20 ± 0.08 |
Epibatidine | 0.2 ± 0.06 | 9 ± 3 | 1.35 ± 0.07 |
(+)-Anatoxin-a | 8 ± 3 | 380 ± 200 | 0.55 ± 0.02 |
Anabasine | 1800 ± 800 | 390 ± 200 | 0.35 ± 0.04 |
Nornicotine | 1000 ± 300 | 2830 ± 960 | 0.27 ± 0.08 |
The agonist concentrations nanomolar that produced 50% inhibition of [3H]GABA release (IC50) were determined as described in Experimental Procedures. The agonist concentrations nanomolar that produced 50% of maximal release (EC50) and the maximal release itself (in units) are from Lu et al., 1998. Each value is the mean ± S.E.