Affinities for inhibition of NTCP-mediated taurocholate uptake by bile acids, organic anion (bromosulfophthalein), and drugs
| Inhibitor | IC50 |
|---|---|
| μM | |
| Cyclosporin | 1.0 |
| Ursodeoxycholic acid | 3.6 |
| Cholic acid | 5.3 |
| (R)-Propranolol | 5.5 |
| (S)-Propranolol | 6.1 |
| Bromosulfophthalein | 7.3 |
| Furosemide | 15 |
| Ketoconazole | 264 |
Values are inhibitory constant, IC50, derived from studies (n = 3) carried out on 3 or more study days.