Table 3

Magnitude of rightward shift for dose-effect curves of U50,488 and bremazocine in antinociception after nor-BNI pretreatment

Days after nor-BNIDose Ratios3-a
i.c. nor-BNI 0.32 mgi.c. nor-BNI 0.032 mgs.c. nor-BNI 0.32 mg
versus U50,488versus bremazocineversus U50,488versus bremazocineversus U50,488versus bremazocine
19.53-150 3.03-150 1.0
31.80.91.0
77.53-150 2.53-150 1.2
101.90.81.0
143.93-150 1.0
217.93-150 0.8
282.01.0
355.43-150 0.7
420.7
491.5
561.0
631.0
  • 3-a Dose ratios were mean of individual dose ratio values (n = 4).

  • 3-150 Significant rightward shift of dose-effect curve *p < .05.