Table 4

Urine conjugate excretion ratios

RatioDeuterium-LabeledUnlabeled
Blacks (n = 51)Whites (n = 57)Blacks (n = 51)Whites (n = 57)
Embedded Image 0.444-160  (0.30–0.59)1.11  (0.74–1.47)0.94  (0.53–1.34)1.52  (0.93–2.10)
Embedded Image 0.254-160  (0.20–0.30)0.40  (0.33–0.46)0.35  (0.29–0.42)0.46  (0.40–0.52)
Embedded Image 0.31***  (0.24–0.39)0.74  (0.37–1.11)0.71***  (0.55–0.87)1.90  (1.57–2.22)
Embedded Image 0.21***  (0.17–0.25)0.35  (0.31–0.38)0.35***  (0.29–0.41)0.61  (0.57–0.65)
Embedded Image 0.38  (0.26–0.51)0.35  (0.30–0.40)0.26  (0.22–0.31)0.28  (0.24–0.33)
Embedded Image 0.24  (0.20–0.28)0.25  (0.22–0.28)0.20  (0.17–0.22)0.21  (0.19–0.24)

Based on recovery in 8-h collections during and after infusion of labeled nicotine and cotinine. The minor metabolites nicotineN′-oxide, cotinine N-oxide, and nornicotine were not measured.

  • 4-160P < .01, *** P < .001; mean (95% CI).