Table 1

Pharmacodynamic modeling of MPA concentrations and effect on lymphocyte function values are estimates ± S.E.M. of IC₅₀, I_max, and Hill factor (n_H).

	I_max	IC₅₀	n_H
	%	mg/l
[³H]TdR
In vitro	99 ± 0.4	0.14 ± 0.00^1-a	0.26 ± 0.02
Single dose	99 ± 1.1	0.19 ± 0.01^1-b	0.11 ± 0.01
Multiple dose	98 ± 1.5	0.18 ± 0.01^1-b	0.23 ± 0.06
S-G₂M
In vitro	93 ± 1.5	0.28 ± 0.01^1-a	0.32 ± 0.04
Single dose	88 ± 0.9	0.70 ± 0.01^1-b	0.56 ± 0.03
Multiple dose	98 ± 1.6	0.83 ± 0.02^1-b	0.79 ± 0.11
CD25
In vitro	74 ± 1.7	0.29 ± 0.01^1-a	0.32 ± 0.01
Single dose	63 ± 1.0	0.65 ± 0.02^1-b	0.40 ± 0.03
Multiple dose	60 ± 1.1	0.81 ± 0.02^1-b	0.67 ± 0.04
CD134
In vitro	83 ± 1.8	0.24 ± 0.02^1-a	0.34 ± 0.04
Single dose	72 ± 1.2	0.61 ± 0.02^1-b	0.42 ± 0.04
Multiple dose	77 ± 1.6	0.74 ± 0.03^1-b	0.57 ± 0.09

↵1-a Blood concentration.
↵1-b Plasma concentration.