Pharmacodynamics
| Strain | NObs | ke0 | Emax | Cpss50 | RMSE | MIC | MTD |
|---|---|---|---|---|---|---|---|
| h−1 | lnCFU · g−1 | μg · ml−1 | μg · ml−1 | mg · kg−1 | |||
| P30923 | 24 | 0.0026 | 13.77 | 0.00180 | 1.1778 | 0.1 | 5 |
| P52181 | 52 | 0.0106 | 9.76 | 0.00488 | 2.1379 | 0.03 | 5 |
| P31192 | 43 | 0.0015 | 8.24 | 0.00859 | 2.2389 | 0.5 | 25 |
| P40225 | 35 | 0.0125 | 7.01 | 0.01139 | 1.1656 | 0.5 | 10 |
| P30189 | 26 | 0.0373 | 9.55 | 0.02116 | 1.2212 | 0.5 | 10 |
| P54B | 76 | 0.0074 | 8.56 | 0.04851 | 1.2608 | 1 | 50 |
| P12698 | 121 | 0.0013 | 16.76 | 0.86001 | 1.8943 | 2 | 100 |
| P54988 | 97 | 0.0191 | 15.53 | 1.08820 | 1.6190 | 1 | 50 |
| P15986 | 75 | 0.0100 | 3.83 | 3.02760 | 1.0599 | 2 | 300 |
| P41375 | 61 | 0.0027 | 6.89 | 4.54140 | 0.7762 | 4 | |
| P53681 | 46 | 0.0031 | 5.58 | 8.67750 | 0.6882 | 8 | |
| P40422 | 57 | 0.0395 | 5.06 | 27.82700 | 1.0769 | 2 | 150 |
Individual parameters have been obtained by post hoc (Bayesian) procedure. Therefore, some shrinkage to the mean may exist, especially in strains with a small number of observations. MIC and MTD (determined in previous studies) are reported in this table for the purpose of comparison between these conventional PD parameters and PD parameters described in the present study (especially Cpss50). Objective function (−2 log likelihood) for the full model, 1487.933; with no interstrain variability in ke0, 1508.931; in Emax, 1681.108; and in Cpss50, 1508.978. Differences between objective function for the full model and these reduced models are all significant at P < .0001.
NObs, number of observations (lnCFU · g−1 − time points for each strain); RMSE, root mean square error.