Table 1

Effects of RWJ 24517 on AP parameters in the presence and absence of 3 μM STX

Condition	RMP	AMP	APD₂₀	APD₅₀	APD₉₀
	mV		ms
Control	−82 ± 0.5	136 ± 1	132 ± 14	208 ± 22	230 ± 24
3 μM STX	−83 ± 0.5	132 ± 1^1-a	126 ± 14	190 ± 22	210 ± 24
3 μM STX + 0.1 μM RWJ 24517	−83 ± 0.6	130 ± 1^1-a	130 ± 14	200 ± 24	221 ± 27
0.1 μM RWJ 24517	−83 ± 0.5	135 ± 1	184 ± 20^1-a	303 ± 31^1-a	333 ± 35^1-a
Washout	−82 ± 0.5	133 ± 1	119 ± 21	214 ± 18	242 ± 24

APs recorded during stimulation at a frequency of 0.2 Hz at 35°C.

RMP, resting membrane potential; AMP, AP amplitude; APD₂₀, APD₅₀, and APD₉₀, APDs measured at 20, 50, and 90% of repolarization, respectively. Data are expressed as mean ± S.E. (n = 5). Statistical analysis was performed with ANOVA.
↵1-a p < .05 with Dunnett’s t test for post hoc comparison of the individual mean values with the control mean value.