Effects of protection protocol on noradrenaline-mediated positive inotropic response in electrically field-driven isolated rat left atria
| n | pD2 | Rmax | |
|---|---|---|---|
| mg | |||
| Control | 9 | 5.10 ± 0.02 | 215 ± 27 |
| 5-MU protected | 5 | 4.62 ± 0.30 | 123 ± 9 |
| BMY7378 protected | 5 | 45 ± 15 |
Preparations were preincubated with selective antagonists (5-MU 0.3 μM or BMY7378 0.5 μM) for 20 min, further incubated with the irreversible α1-adrenoceptor antagonist POB (0.3 μM) for 30 min, and then washed 7 times.
4-150 p < .05, compared with control.