Protease inhibitory activity of the matrix metalloproteinase MMP Inhibitor PD 166793
| Enzyme Classification | IC502-a | ||
|---|---|---|---|
| μM | |||
| MMP2-b | |||
| Interstitial collagenase | |||
| MMP-1 | 6.100 | ||
| Stromelysins | |||
| MMP-3 | 0.012 | ||
| MMP-7 | 8.100 | ||
| Gelatinases | |||
| MMP-2 | 0.047 | ||
| MMP-9 | 9.900 | ||
| ACE | >100 (n/c)2-c | ||
| Neutral endopeptidase | >100 (n/c)2-c | ||
| Endothelin-converting enzyme | >100 (n/c)2-c | ||
| Tumor necrosis factor α-converting enzyme | >100 (n/c)2-c |
↵2-a Data expressed as concentration necessary to inhibit 50% of maximal enzyme activity.
↵2-b MMP activity assays determined with recombinant human MMP constructs of the catalytic domain and an artificial substrate assay system.
↵2-c PD166793 was not active at up to 100 μM and therefore a true IC50 was not computed (n/c).