Inhibition of LPS-induced TNF-α production in mice by RWJ 67657 and SB 203580
| Compound | Dose | Expts. | Inhibition of Serum TNF-α |
|---|---|---|---|
| mg/kg | n | % | |
| RWJ 67657 | 25 | 4 | 48 ± 205-150 |
| 40 | 1 | 72 ± 115-150 | |
| 50 | 4 | 87 ± 95-150 | |
| SB 203580 | 25 | 4 | 89 ± 15-150 |
Mice were injected with LPS i.p. 30 min after oral dosing with compound. Blood was collected 1 h later, serum was prepared, and TNF-α levels were measured by ELISA as described inExperimental Procedures.
↵5-150 p < .01 for comparison of TNF-α levels in compound-treated versus vehicle-treated mice.