Cellular specificity of RWJ 67657 and SB 203580
| Compound | SEB/PBMC | |||
|---|---|---|---|---|
| TNF-α IC50 | IL-2 | IFN-γ | T Cell Proliferation | |
| nM | % inhibition | |||
| RWJ 67657 | 13 ± 6 | Inactive | Inactive | Inactive |
| SB 203580 | 122 ± 48 | Inactive | Inactive | Inactive |
Cytokine production was assayed at 18 to 24 h poststimulation. Proliferation was assayed at 4 days. Values are the mean of three or four experiments ±1 S.D.
Inactive indicates no significant inhibition at the highest concentration tested (10 μM).