Table 3

Effects of pretreatment with 100 μM CEC on antagonism by BMY 7378 or RS 17053

Antagonist (concentration)pKB (control-no CEC)pKB (after 30 min CEC)
BMY 7378ND7.88  ± 0.19
(100 nM)(n  = 4)
BMY 73787.06  ± 0.077.30  ± 0.22
(1000 nM)(n  = 4)(n  = 4)
RS 17053ND8.55  ± 0.193-150
(30 nM)(n  = 5)
RS 170537.48  ± 0.187.62  ± 0.11
(300 nM)(n  = 5)(n  = 5)
  • ND, not done.

  • 3-150  Significantly different (p < .05) from values for RS 17053 at 300 nM.

  • Values are mean ± S.E.