Table 1

pK_B values for non- or α_1D-selective adrenoceptor antagonists against PE-induced contractions of DMA

Antagonist	3 nM	30 nM	300 nM	3,000 nM
Prazosin^1-150	9.58 ± 0.29 (4)	8.17 ± 0.26 (4)	7.37 ± 0.21 (4)
WB4101	9.80 ± 0.07 (7)	9.38 ± 0.07 (7)	≥9.4^1-160

	10 nM	100 nM	1000 nM
MDL 73005EF^1-150	8.02 ± 0.12 (4)	7.00 ± 0.11 (4)	6.48 ± 0.16 (4)

	100 nM	300 nM	1,000 nM	3,000 nM	10,000 nM
BMY7378	7.34 ± 0.05 (8)	7.29 ± 0.06 (8)	7.06 ± 0.06 (8)
SK&F 105854	7.14 ± 0.17 (5)	6.87 ± 0.18 (4)	7.12 ± 0.12 (7)	6.72 ± 0.08 (7)	6.69 (2)

↵1-150 Values significantly different from one another,p < .05.
↵1-160 Effect of 300 nM WB 4101 could not be surmounted by 2.2 mM PE (i.e., less that 50% of control response achieved; pK_B ≥ 9.4).
Values are mean ± S.E.