EC50 values for melatonin on μOR/RGS-expressing cells
| Cells | 30 min | 60 min | 120 min |
|---|---|---|---|
| pM | |||
| μOR/lacZ | 31.8 ± 9.1 | 48.5 ± 7.1 | 78.2 ± 7.1 |
| μOR/RGS1/lacZ | 25.1 ± 2.9 | 42.2 ± 5.1 | 72.1 ± 6.6 |
| μOR/RGS2/lacZ | 32.6 ± 1.9 | 56.6 ± 6.4 | 88.8 ± 9.3 |
| μOR/RGS3/lacZ | 23.3 ± 4.5 | 40.7 ± 10.8 | 65.3 ± 21.1 |
| μOR/RGS4/lacZ | 38.4 ± 12.2 | 51.0 ± 8.9 | 74.6 ± 5.2 |
| lacZ | 47.2 ± 20.4 | 65.0 ± 34.8 | 87.1 ± 29.5 |
Data are expressed as mean ± S.D. (n = 3). There were no comparisons giving values of p ≤ .0124, compared with the corresponding μOR/lacZ sample value. Data are representative of at least duplicate experiments.