EC50 values for morphine on μOR/RGS-expressing cells
| Cells | 30 min | 60 min | 120 min |
|---|---|---|---|
| nM | |||
| μOR/lacZ | 14.3 ± 4.3 | 21.8 ± 3.6 | 44.9 ± 13.9 |
| μOR/RGS1/lacZ | 8.44 ± 1.89 | 9.04 ± 7.40 | 23.6 ± 22.8 |
| μOR/RGS2/lacZ | 32.0 ± 7.41-150 | 45.9 ± 4.01-150 | 76.7 ± 12.9 |
| μOR/RGS3/lacZ | 11.5 ± 1.5 | 15.2 ± 2.5 | 23.4 ± 6.4 |
| μOR/RGS4/lacZ | 23.7 ± 5.2 | 36.5 ± 1.5 | 48.1 ± 12.0 |
| lacZ | None | None | None |
Data are expressed as mean ± S.D. (n = 3). Data are representative of at least duplicate experiments.
↵1-150 p ≤ .0124, compared with the corresponding μOR/lacZ sample value.