Table 2

Comparison of alkaloid effects on MEPP amplitudes

MLA14-DNBarbinineDeltaline
Controls
 Mean (mV ± S.D.)2-a 0.65  ± 0.120.75  ± 0.140.54  ± 0.080.83  ± 0.09
 Mean coefficient of variation2-a 0.17  ± 0.030.16  ± 0.030.23  ± 0.100.15  ± 0.03
 No. of MEPPs618 376 337 249
 No. of animals  7   5   4   5
[Alkaloid] (μM)  0.10  0.05  0.50 20
 Mean (mV ± S.D.)2-a 0.46  ± 0.08** 0.53  ± 0.102-150 0.34  ± 0.06** 0.51  ± 0.10***
 Mean coefficient of variation2-a 0.17  ± 0.020.15  ± 0.040.19  ± 0.020.13  ± 0.03
 No. of MEPPs599 362 256 141
 No. of animals  7   5   4   5
Rinse
 Mean (mV ± S.D.)2-a 0.57  ± 0.12**** 0.67  ± 0.02**** 0.50  ± 0.10**** 0.75  ± 0.02****
 Mean coefficient of variation2-a 0.19  ± 0.030.15  ± 0.020.23  ± 0.030.17  ± 0.02
 Total no. of MEPPs438 300 252 154
 No. of animals  5   4   3   3 
  • 2-a MEPP amplitudes and coefficients of variation are each expressed as the mean of the average value measured in each muscle fiber.

  • 2-150p < .05 less than control. ** p < .01 less than control. *** p < .001 less than control. **** p > .1 compared with controls.