Table 1

Comparison of alkaloid effects on CMAP and MEPP amplitudes

Nudicauline14-DNMLABarbinineDeltaline
IC50 for CMAPs (μM)0.32  ± 0.030.62  ± 0.051.48  ± 0.113.2  ± 1.74156  ± 11.08
Slope3.55  ± 0.872.53  ± 0.453.52  ± 0.541.45  ± 0.273.62  ± 0.75
MEPP inhibition (%)1-a 29  ± 628  ± 439  ± 541  ± 5
 By [alkaloid] (μM)0.050.100.5020.0
  • 1-a Reductions in MEPP amplitude are the mean values of the reduction in each muscle fiber from Table 2.